Final2021 Week 5

State Farm Stadium, Glendale, AZ

San Francisco 49ers vs Arizona Cardinals, Week 5 2021

San Francisco 49ers

Away

10

Arizona Cardinals

HomeWon

17

Scoring by quarter
TeamQ1Q2Q3Q4Final
49ers007310
Cardinals730717

SF 10ARI 17 Final

  • Passing leader

    Kyler Murray

    ARI · QB

    13.7PPR pts

    22/31, 239 YDS, 1 TD

  • Top fantasy scorer

    DeAndre Hopkins

    ARI · WR

    20.7PPR pts

    6 REC, 87 YDS, 1 TD

  • 49ers leader

    Deebo Samuel Sr.

    SF · WR

    16.1PPR pts

    3 REC, 58 YDS, 1 RUSH TD

  • Defensive playmaker

    Budda Baker

    ARI

    1 INT, 6 TKL

Cardinals 17, 49ers 10: Arizona beats San Francisco

Arizona led 10–0 at halftime and won 17–10, though San Francisco took the second half 10–7. San Francisco outgained the Cardinals 338–304.

San Francisco didn't get on the board until the third quarter.

The 49ers went 3-for-11 on third down and committed one turnover.

The two teams meet again in Week 18 of 2026. If you roster anyone from either side, run the start/sit call in Redraft Command and it will weigh your lineup, your opponent and your league scoring, not only the player rankings.

Key advantages

  • +3% third-down rate ARI 30% · SF 27%

Game Highlights

Official NFL highlights · Opens from YouTube

Got a 49er or Cardinal on your fantasy team?

Check their next matchup with the Start/Sit Tool, compare their value in the Fantasy Trade Calculator, or connect your league for personalized advice in Redraft Command.

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Why the Cardinals Won

Arizona won the third-down battle.

Team stats comparison, 49ers vs Cardinals
49ersStatCardinals
27%Third-down conversion30%
Other team stats
338Total yards304
5.7Yards per play5.1
59Plays60
1Turnovers1
31:54Time of possession28:06

Scoring Summary

The Cardinals scored two touchdowns and one field goal; the 49ers scored one touchdown and one field goal.

Scoring plays, 49ers vs Cardinals
TimeTeamPlaySFARI
1st quarter
9:02ARIJames Conner 1-yard TD run Takes leadMatt Prater XP07
2nd quarter
5:27ARIMatt Prater 21-yard FG Extends lead010
3rd quarter
1:42SFDeebo Samuel 13-yard TD runJoey Slye XP710
4th quarter
5:13ARIKyler Murray → DeAndre Hopkins, 9-yard TD Extends leadMatt Prater XP717
4:12SFJoey Slye 47-yard FG1017

Fantasy Points: 49ers vs Cardinals, Week 5 2021

Fantasy leaders

  1. DeAndre HopkinsARIWR20.7 PTSWR15
  2. Deebo SamuelSFWR16.1 PTSWR21
  3. Trey LanceSFQB15.6 PTSQB18
  4. Rondale MooreARIWR14.7 PTSWR26

Player Stats

Quarterbacks

Quarterback statistics
PlayerFPTSFINCMP/ATTPass YDSTDINTRush ATTRush YDSRush TDRateStart/Sit
Kyler MurrayARIQB11.7QB2522/3123910710104.1Start/Sit →
Trey LanceSFQB15.6QB1815/29192011689058.4Start/Sit →

WRs, RBs, & TEs

Receiver, running back and tight end statistics
PlayerFPTSFINPOSRush ATTRush YDSRush TDTGTRECRec YDSRec TDStart/Sit
DeAndre HopkinsARIWR20.7WR15WR———96871
Deebo SamuelSFWR16.1WR21WR113193580
Rondale MooreARIWR14.7WR26WR338065590
James ConnerARIRB10.7RB32RB102911180
Christian KirkARIWR10.0WR43WR111055390
Elijah MitchellSFRB8.2RB39RB943022190
Brandon AiyukSFWR5.2WR79WR———42320
Ross DwelleySFTE4.5TE32TE———22250
Mohamed SanuSFWR3.9WR89WR———32190
Chase EdmondsARIRB3.4RB55RB615043190
Maxx WilliamsARITE2.4TE48TE———11140
A.J. GreenARIWR2.3WR102WR———21130
Charlie WoernerSFTE1.4TE59TE———1140Start/Sit →
Trey SermonSFRB0.7RB75RB170————
Travis BenjaminSFWR0.0—WR———3000

Fantasy Usage

San Francisco 49ers

Snap Share

  1. Ross DwelleyTE59 snaps91%
  2. Deebo SamuelWR56 snaps86%
  3. Brandon AiyukWR46 snaps71%
  4. Elijah MitchellRB44 snaps68%
  5. Mohamed SanuWR30 snaps46%

Target Share24 targets

  1. Deebo Samuel38%, 9 targets
  2. Brandon Aiyuk17%, 4 targets
  3. Mohamed Sanu13%, 3 targets
  4. Travis Benjamin13%, 3 targets
  5. Ross Dwelley8%, 2 targets
  6. Other13%, 3 targets

Carry Share27 carries

  1. Trey Lance59%, 16 carries
  2. Elijah Mitchell33%, 9 carries
  3. Deebo Samuel4%, 1 carries
  4. Trey Sermon4%, 1 carries

Arizona Cardinals

Snap Share

  1. DeAndre HopkinsWR56 snaps92%
  2. A.J. GreenWR49 snaps80%
  3. Chase EdmondsRB37 snaps61%
  4. Christian KirkWR33 snaps54%
  5. Demetrius HarrisTE32 snaps52%

Target Share28 targets

  1. DeAndre Hopkins32%, 9 targets
  2. Rondale Moore21%, 6 targets
  3. Christian Kirk18%, 5 targets
  4. Chase Edmonds14%, 4 targets
  5. A.J. Green7%, 2 targets
  6. Other7%, 2 targets

Carry Share27 carries

  1. James Conner37%, 10 carries
  2. Kyler Murray26%, 7 carries
  3. Chase Edmonds22%, 6 carries
  4. Rondale Moore11%, 3 carries
  5. Christian Kirk4%, 1 carries
View full usage tableHide full usage table
Offensive snaps and share for the skill positions
PlayerSNAPSSNAP %TGTTGT %CAR
DeAndre HopkinsARIWR5692%932%0
Ross DwelleySFTE5991%28%0
Deebo SamuelSFWR5686%938%1
A.J. GreenARIWR4980%27%0
Brandon AiyukSFWR4671%417%0
Elijah MitchellSFRB4468%28%9
Chase EdmondsARIRB3761%414%6
Christian KirkARIWR3354%518%1
Demetrius HarrisARITE3252%00%0
James ConnerARIRB2948%14%10
Rondale MooreARIWR2948%621%3
Mohamed SanuSFWR3046%313%0
Maxx WilliamsARITE2541%14%0
Charlie WoernerSFTE2132%14%0
Travis BenjaminSFWR1523%313%0
Ross TravisARITE915%00%0
Trent SherfieldSFWR914%00%0
Antoine WesleyARIWR35%00%0
Trey SermonSFRB23%00%1
Tanner HudsonSFTE12%00%0

Fantasy Points vs Expected

Expected points (xFP) are what a player's pass attempts, carries and targets are worth at the league's average rates; the difference is what the player made of them.

  • Biggest overperformer+5.5DeAndre Hopkins20.7 PTS vs 15.2 xFP
  • Biggest underperformer−7.4Trey Lance15.6 PTS vs 23.0 xFP
  • Highest expected volume23.0 xFPTrey Lance15.6 PTS scored
Usage and expected fantasy points
PlayerPTSxFPvs xFPSnap%UsageRte%Pass attCarCar%TgtTgt%
Trey LanceSF · QB15.623.0−7.4100%29 att—291657%00%
Kyler MurrayARI · QB13.718.1−4.4100%31 att—31726%00%
Deebo Samuel Sr.SF · WR16.115.8+0.386%32% tgt—014%932%
DeAndre HopkinsARI · WR20.715.2+5.592%32% tgt—000%932%
Rondale MooreARI · WR14.712.0+2.748%21% tgt—0311%621%
Chase EdmondsARI · RB4.410.6−6.261%22% car—0622%414%
Christian KirkARI · WR10.09.1+0.954%18% tgt—014%518%
Elijah MitchellSF · RB8.29.1−0.968%32% car—0932%27%
James ConnerARI · RB10.78.1+2.648%37% car—01037%14%
Kyle JuszczykSF · RB6.57.4−0.9—14% tgt—014%414%
Brandon AiyukSF · WR5.26.7−1.571%14% tgt—000%414%
Mohamed SanuSF · WR3.95.1−1.246%11% tgt—000%311%
Travis BenjaminSF · WR0.05.1−5.123%11% tgt—000%311%
A.J. GreenARI · WR2.33.4−1.180%7% tgt—000%27%
Ross DwelleySF · TE4.53.4+1.191%7% tgt—000%27%
Charlie WoernerSF · TE1.41.7−0.332%4% tgt—000%14%
Maxx WilliamsARI · TE2.41.7+0.741%4% tgt—000%14%
Trey SermonSF · RB0.70.6+0.13%4% car—014%00%

Team totals: 49ers 28 targets and 28 carries; Cardinals 28 targets and 27 carries. Shares are from the box score. Snap counts are from the weekly player logs (Sleeper), and include plays wiped out by penalties. Route counts, air yards and red-zone touches appear when the tracking feed is connected. League-average rates from the 2021 season: 1.68 PPR points per target (67% catch rate), 0.64 per carry and 0.44 per pass attempt. They don't adjust for field position or target depth.

Fantasy Verdicts

Trey Lance Unlucky

SF · QB · 15.6 pts on 23.0 expected

15 of 29 passing for 192 yards, 1 interception; 16 carries for 89 yards.

Verdict: The role was there, worth 23.0 points at league-average rates; the production wasn't.

Start/Sit: Trey Lance →

Kyler Murray

ARI · QB · 13.7 pts on 18.1 expected

22 of 31 passing for 239 yards, 1 touchdown; 7 carries for 1 yard.

Verdict: The points matched the role, 18.1 expected.

Start/Sit: Kyler Murray →

Deebo Samuel Sr. Strong role

SF · WR · 16.1 pts on 15.8 expected

9 targets (32% of the team's), 3 catches for 58 yards; 1 carry (4% of the team's) for 13 yards and 1 touchdown.

Verdict: The points matched the role, 15.8 expected.

Elijah Mitchell

SF · RB · 8.2 pts on 9.1 expected

2 targets (7% of the team's), 2 catches for 19 yards; 9 carries (32% of the team's) for 43 yards.

Verdict: The points matched the role, 9.1 expected.

DeAndre Hopkins Ran hot

ARI · WR · 20.7 pts on 15.2 expected

9 targets (32% of the team's), 6 catches for 87 yards and 1 touchdown.

Verdict: The opportunities were worth 15.2 points; the touchdowns supplied the rest, and they are the part least likely to repeat.

Rondale Moore

ARI · WR · 14.7 pts on 12.0 expected

6 targets (21% of the team's), 5 catches for 59 yards; 3 carries (11% of the team's) for 38 yards.

Verdict: The points matched the role, 12.0 expected.

Chase Edmonds Unlucky

ARI · RB · 4.4 pts on 10.6 expected

4 targets (14% of the team's), 3 catches for 19 yards; 6 carries (22% of the team's) for 15 yards.

Verdict: The role was there, worth 10.6 points at league-average rates; the production wasn't.

Travis Benjamin Unlucky

SF · WR · 0.0 pts on 5.1 expected

3 targets (11% of the team's), 0 catches for 0 yards.

Verdict: The role was there, worth 5.1 points at league-average rates; the production wasn't.

Stock Up, Stock Down

San Francisco 49ers

  • Stock up: Ross Dwelley played 91% of the snaps, up from a 21% season average.
  • Stock up: Charlie Woerner played 32% of the snaps, up from a 12% season average.
  • Stock down: Trey Sermon played 3% of the snaps, down from a 37% season average.

Arizona Cardinals

  • Stock down: Maxx Williams played 41% of the snaps, down from a 72% season average.

Fantasy Matchups

Fantasy points allowed per game by position, 2021 through Week 18.

Fantasy points allowed per game by position, 49ers defense and Cardinals defense
Points allowed to49ers DCardinals D
QBs17.716.5
RBs20.920.5
WRs35.437.9
TEs9.17.7

Regular season, summed from each game's box score and scored with this page's rules.

How the Game Swung

Arizona opened at 66% win probability and passed 98% in the fourth quarter on the way to the win.

Cardinals win probability

Cardinals win probability by game minuteCardinals started at 66%, stood at 91% at halftime and finished at 100%, across 5 scoring plays.Q1Q2Q3Q4100%50%0%

Key Swings

  1. +17Conner 1-yd TD run65% → 82%Q1 9:02
  2. +6Prater 21-yd FG84% → 90%Q2 5:27
  3. −21Samuel 13-yd TD run95% → 74%Q3 1:42
  4. +19Murray → Hopkins, 9-yd TD81% → >99%Q4 5:13
  5. −2Slye 47-yd FG>99% → 98%Q4 4:12

Swing in Cardinals win probability, in points

Play Calling and Possessions

Play calling, 49ers vs Cardinals
San Francisco 49ersMeasureArizona Cardinals
59Plays60
53%Pass rate55%
6.0Yds / dropback6.4
5.4Yds / carry3.5
3/11Third downs3/10

Efficiency edge Arizona ran 1 more plays than San Francisco.

  • Top targets
  • SF Samuel 32% · Aiyuk 14% · Juszczyk 14%
  • ARI Hopkins 32% · Moore 21% · Kirk 18%

Possession Results

How each possession ended, 49ers vs Cardinals
ResultSFARI
Touchdowns12
Field goals11
Punts24
Turnovers11
Turnovers on downs40
Missed field goals01
  • The Cardinals opened the scoring on their first possession, a 8-play, 66-yard drive that ended in a touchdown.
All 19 possessions, drive by drive
Drive chart
TeamStartPlaysYardsTimeResult
SFQ1 15:004302:14Interception
ARIQ1 12:468663:44Touchdown
SFQ1 9:027424:17Downs
ARIQ1 4:45352:21Punt
SFQ1 2:2413935:58Downs
ARIQ2 11:2614965:59Field goal
SFQ2 5:273-11:43Punt
ARIQ2 3:4411273:44Missed FG
ARIQ3 15:00381:10Punt
SFQ3 13:5010187:30Punt
ARIQ3 6:20351:10Punt
SFQ3 5:106593:28Touchdown
ARIQ3 1:426252:31Punt
SFQ4 14:117324:53Downs
ARIQ4 9:18250:39Fumble
SFQ4 8:39460:50Downs
ARIQ4 7:495522:36Touchdown
SFQ4 5:136461:01Field goal
ARIQ4 4:127184:12End of game
About these numbers

Possessions that ended with the clock running out at the half or the end of the game aren't counted.

Personnel groupings, average depth of target and pass rate over expected appear when the tracking feed is connected.

49ers vs Cardinals Head-to-Head

The 49ers and Cardinals first met in 1951 and have played 70 times since. They have been NFC West rivals since 2002.

All-time series
39–3149ers lead, 70 meetings since 1951
Postseason
0No playoff meetings
Largest 49ers win
50–142003
Largest Cardinals win
47–72015

Since 2021

7–4 49ers lead

11 meetings since the 2021 season, regular season and playoffs.

Oldest to newest. 4 = 49ers win, C = Cardinals win, outlined = this game.

2026 Meetings

  • Week 18 49ers at Cardinals Upcoming

Recent Meetings

Season to Date (Through Week 18)

The 2021 regular season, from each game's box score.

Season to date, 49ers vs Cardinals
49ersStatCardinals
10-7Record11-6
25.1Points per game26.4
375.7Yards per game373.6
6.1Yards per play5.6
21.5Points allowed per game21.5
310.0Yards allowed per game329.2

49ers vs Cardinals Odds and Results

How this game finished against the betting lines.

Spread
ARI −5.5Cardinals covered by 1.5
Total
48.5Under: 27 points scored (by 21.5)

Expected vs Actual Scoring

Implied team totals against the actual score
TeamImpliedActualDifference
Cardinals27.017−10.0
49ers21.510−11.5

Both offenses finished under the market's expectation, which matches the low fantasy output in the Fantasy tab.

Betting Trends

Each team's 2021 season through this game. Over/under is overs first.

San Francisco 49ers

Against the spread
1–4
Over/under
2–3
ATS as favorite
1–3
ATS as underdog
0–1
ATS on the road
1–2

Arizona Cardinals

Against the spread
4–1
Over/under
2–3
ATS as favorite
2–1
ATS as underdog
2–0
ATS at home
1–1

Lines: ESPN's consensus, captured at kickoff. Individual sportsbooks varied.

21+. Gambling problem? Call 1-800-GAMBLER. Betting availability depends on your state.

49ers vs Cardinals Fantasy Outlook for 2026

One meeting is left on the 2026 schedule: Week 18 in Arizona. Here's how to decide who to play in your league.

Keep Exploring

2021 Game Logs for Players in This Game

49ers vs Cardinals Game FAQ

Who won the 2021 49ers vs Cardinals Week 5 game?

The Arizona Cardinals beat the San Francisco 49ers 17–10 in Week 5 of the 2021 season. The game was played at State Farm Stadium in Glendale, AZ, on October 10, 2021. See the Cardinals' 2021 schedule.

What was the final score of 49ers vs Cardinals?

The final score was Cardinals 17, 49ers 10. The Cardinals led 10–0 at halftime, and the second half went 49ers 10, Cardinals 7.

What happened in the 49ers vs Cardinals game?

Arizona led 10–0 at halftime and won 17–10, though San Francisco took the second half 10–7. San Francisco outgained the Cardinals 338–304. DeAndre Hopkins led all players with 6 catches for 87 yards and a touchdown.

Who scored the most fantasy points in 49ers vs Cardinals?

DeAndre Hopkins led the game with 20.7 PPR fantasy points, the WR15 of Week 5, on 6 catches for 87 yards and a touchdown. Deebo Samuel was next with 16.1 (WR21).

Who led 49ers vs Cardinals in passing, rushing and receiving?

Kyler Murray (ARI) led all passers with 22 of 31 for 239 yards and a touchdown. Trey Lance (SF) led in rushing with 16 carries for 89 yards. DeAndre Hopkins (ARI) led in receiving with 6 catches for 87 yards and a touchdown.

How many fantasy points did DeAndre Hopkins score against the 49ers?

DeAndre Hopkins scored 20.7 points in PPR leagues, 17.7 in half-PPR and 14.7 in standard scoring against the 49ers in Week 5 of the 2021 season, on 6 catches for 87 yards and a touchdown. He drew 32% of his team's targets.

Who outperformed and underperformed expected fantasy points in 49ers vs Cardinals?

DeAndre Hopkins outperformed his expected fantasy points the most, scoring 20.7 PPR points on 15.2 xFP (+5.5). Trey Lance fell furthest short, with 15.6 points on 23.0 xFP (−7.4). A gap either way reflects efficiency and touchdowns in one game; it is not a forecast. For matchups ahead, see fantasy points allowed by position.

Who had the highest expected fantasy points in 49ers vs Cardinals?

Trey Lance had the most fantasy opportunity in the game, worth 23.0 expected PPR points (xFP) at league-average rates, and scored 15.6. Expected points measure the volume of a player's pass attempts, carries and targets, not how well he used them.

What is the all-time 49ers vs Cardinals record?

The 49ers lead the all-time series 39–31 across 70 meetings since 1951.

When did the 49ers and Cardinals last play before this game?

Before Week 5 of 2021, they last met in the 2020 season on December 26, 2020, when the 49ers beat the Cardinals 20–12.

What is the 49ers vs Cardinals record since 2021?

The 49ers lead 7–4 across 11 meetings since the 2021 season, including this game.

What was the closing spread for 49ers vs Cardinals?

The consensus closing spread at kickoff was Cardinals −5.5, making the Arizona Cardinals 5.5-point favorites, with a closing total of 48.5. That implied about 27.0 points for the Cardinals and 21.5 for the 49ers.

Did 49ers vs Cardinals go over or under the total?

The game went under. The consensus closing total was 48.5, and the teams combined for 27 points, 21.5 under the number.

Who covered the spread in 49ers vs Cardinals?

The Cardinals covered by 1.5 against the closing line of Cardinals −5.5. The final margin was 7 points.