Isaac Guerendo Injury status and history
- Age
- 26
- Height / weight
- 6'0", 221 lb
- Experience
- 3rd season
- Drafted
- 2024 R4, #129
2024 Season
- PPR PPG
- 6.3
- Pos rank
- RB52
- Rostered
- —
Week 4 vs. Broncos, Sun Oct 4, 4:25 PM ET 6th vs. RBs, favorable
Isaac Guerendo Injury Update & History
Guerendo is on the PUP list with a pectoral injury.
Practice participation
Final report: Friday, Oct 2Guerendo hasn't appeared on an injury report this season.
Injury History at a Glance
Five logged injuries in one season. Most of his lost time came from a hamstring injury in 2024; nothing else has cost him a game.
Durability
100/100
Games missed
Injuries
Longest absence
Hamstring injury · 2024
Where He's Been Hurt
Marker size shows games missed. A dashed ring means he played through it.
| Body part | Injuries | Games missed |
|---|---|---|
| Hamstring | 1 | 1 |
| Foot / toe | 1 | 0 |
| Knee | 1 | 0 |
| Other | 1 | 0 |
| Shoulder | 1 | 0 |
| Total | 5 | 1 |
Injury risk profile: Moderate
- No body part injured twice
- Questionable in 2025, played through
- 1 game in 1 season
- 5 injuries spread across 5 body parts
Isaac Guerendo Injury History
Every logged injury, most recent first. Games missed are regular-season games.
- 2025
Questionable Played through
Week 18 · with the 49ers
Questionable
- 2025
Shoulder Played through
Preseason · with the 49ers
Dealt with a shoulder injury during the 2025 preseason that he appeared to re-aggravate in a game.
- 2024
Knee Played through
Week 18 · with the 49ers
Sustained a knee injury at the end of the 2024 season that he was still dealing with in the subsequent preseason.
- 2024
Hamstring 1 game
Week 15 · with the 49ers
Suffered a hamstring injury in the Week 15 game against the Los Angeles Rams and was considered unlikely to play the following week.
- 2024
Foot Sprain Played through
Week 14 · with the 49ers
Suffered a foot sprain during his first-career start in Week 14 against the Chicago Bears.
All Isaac Guerendo stats & analysis
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Isaac Guerendo Injury FAQ
Is Isaac Guerendo injured?
Yes. As of October 2, 2026, Isaac Guerendo is pup list with a pectoral injury. He has missed 3 games this season. See how the injury changes his rest-of-season value.
Is Isaac Guerendo playing this week?
No. Isaac Guerendo is pup list for Week 4 against the Broncos on Sunday, October 4. Should you start him?
What injury does Isaac Guerendo have?
Isaac Guerendo has a pectoral injury and is pup list for Week 4. He has missed 3 games this season.
Why isn't Isaac Guerendo playing?
Isaac Guerendo is pup list with a pectoral injury, the designation his club filed as of October 2, 2026. That rules him out of Week 4.
Has Isaac Guerendo missed any games this season?
Yes. Isaac Guerendo has missed 3 games in 2026 and played in 0.
What is Isaac Guerendo's injury history?
Isaac Guerendo has 5 logged NFL injuries, which have cost him 1 game in all: 1 for a hamstring injury in 2024. No body part has been injured twice.
What was Isaac Guerendo's most recent injury?
Isaac Guerendo's most recent logged injury was a questionable injury in Week 18 of 2025. He played through it and missed no regular-season games.
Does Isaac Guerendo have any recurring injuries?
No. Isaac Guerendo's five logged injuries were to five different body parts, so the record shows no recurring pattern.
What was Isaac Guerendo's worst injury?
Isaac Guerendo's longest absence came from a hamstring injury in 2024, which cost him 1 game, all of the games he has missed to injury.
