Isaac Guerendo headshot

Isaac Guerendo Injury status and history

Age
26
Height / weight
6'0", 221 lb
Experience
3rd season
Drafted
2024 R4, #129

2024 Season

PPR PPG
6.3
Pos rank
RB52
Rostered
—

Week 4 vs. Broncos, Sun Oct 4, 4:25 PM ET 6th vs. RBs, favorable

Isaac Guerendo Injury Update & History

PUP list
Checked

Guerendo is on the PUP list with a pectoral injury.

2026 games missed
3
Last played Week 18, Jan 10
Latest injury
Questionable injury
Week 18, 2025, played through
Next game
Week 4 vs DEN
Sun Oct 4, 4:25 PM ET

Practice participation

Final report: Friday, Oct 2

Guerendo hasn't appeared on an injury report this season.

Injury History at a Glance

Five logged injuries in one season. Most of his lost time came from a hamstring injury in 2024; nothing else has cost him a game.

A+

Durability

100/100

1

Games missed

5

Injuries

1game

Longest absence

Hamstring injury · 2024

Where He's Been Hurt

Marker size shows games missed. A dashed ring means he played through it.

Shoulder2025, played thruHamstring2024, 1 gameKnee2024, played thruFoot2024, played thru
Front view: the player's right side is on your left. Side not recorded for the shoulder, knee, hamstring and foot. Not shown: questionable.
Injuries by body part, regular-season games missed
Body partInjuriesGames missed
Hamstring11
Foot / toe10
Knee10
Other10
Shoulder10
Total51

Injury risk profile: Moderate

  • No body part injured twice
  • Questionable in 2025, played through
  • 1 game in 1 season
  • 5 injuries spread across 5 body parts

Isaac Guerendo Injury History

Every logged injury, most recent first. Games missed are regular-season games.

  1. 2025

    Questionable Played through

    Week 18 · with the 49ers

    Questionable

  2. 2025

    Shoulder Played through

    Preseason · with the 49ers

    Dealt with a shoulder injury during the 2025 preseason that he appeared to re-aggravate in a game.

  3. 2024

    Knee Played through

    Week 18 · with the 49ers

    Sustained a knee injury at the end of the 2024 season that he was still dealing with in the subsequent preseason.

  4. 2024

    Hamstring 1 game

    Week 15 · with the 49ers

    Suffered a hamstring injury in the Week 15 game against the Los Angeles Rams and was considered unlikely to play the following week.

  5. 2024

    Foot Sprain Played through

    Week 14 · with the 49ers

    Suffered a foot sprain during his first-career start in Week 14 against the Chicago Bears.

Injury status is the designation each club has filed, as our last check found it. History covers regular-season games missed. The durability score measures time lost to injury only; games not played as a backup don't count against it. Status last checked . Practice participation is from the league's official injury report on NFL.com, last read .

Fantasy points use PPR scoring.

All Isaac Guerendo stats & analysis

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Isaac Guerendo Injury FAQ

Is Isaac Guerendo injured?

Yes. As of October 2, 2026, Isaac Guerendo is pup list with a pectoral injury. He has missed 3 games this season. See how the injury changes his rest-of-season value.

Is Isaac Guerendo playing this week?

No. Isaac Guerendo is pup list for Week 4 against the Broncos on Sunday, October 4. Should you start him?

What injury does Isaac Guerendo have?

Isaac Guerendo has a pectoral injury and is pup list for Week 4. He has missed 3 games this season.

Why isn't Isaac Guerendo playing?

Isaac Guerendo is pup list with a pectoral injury, the designation his club filed as of October 2, 2026. That rules him out of Week 4.

Has Isaac Guerendo missed any games this season?

Yes. Isaac Guerendo has missed 3 games in 2026 and played in 0.

What is Isaac Guerendo's injury history?

Isaac Guerendo has 5 logged NFL injuries, which have cost him 1 game in all: 1 for a hamstring injury in 2024. No body part has been injured twice.

What was Isaac Guerendo's most recent injury?

Isaac Guerendo's most recent logged injury was a questionable injury in Week 18 of 2025. He played through it and missed no regular-season games.

Does Isaac Guerendo have any recurring injuries?

No. Isaac Guerendo's five logged injuries were to five different body parts, so the record shows no recurring pattern.

What was Isaac Guerendo's worst injury?

Isaac Guerendo's longest absence came from a hamstring injury in 2024, which cost him 1 game, all of the games he has missed to injury.