Isaac Guerendo Fantasy outlook, stats and Week 4 start/sit for 2026
- Age
- 26
- Height / weight
- 6'0", 221 lb
- Experience
- 3rd season
- Drafted
- 2024 R4, #129
2024 Season
- PPR PPG
- 6.3
- Pos rank
- RB52
- Rostered
- —
Week 4 vs. Broncos, Sun Oct 4, 4:25 PM ET 6th vs. RBs, favorable
Isaac Guerendo Fantasy Football Stats & Analysis
Producing as
RB50 · Depth
Scoring rate
6.3 PPG
Played
15 games
Role
Depth
Trend
Heating Up
Role Direction
| Usage | Season | Last 4 | Change |
|---|---|---|---|
| Carries/G | 5.6 | 10.5 | +88% |
| Targets/G | 1.1 | 2.5 | +134% |
Isaac Guerendo's 2026 Season, Week by Week
The next four matchups include one of the league's softest run defenses.
- Week 1, Win,at LAR,—,Did not play
- Week 2, Win,vs MIA,—,Did not play
- Week 3, Win,vs ARI,—,Did not play
- Up next. Week 4, Oct 4,vs DEN,Favorable, OutBroncos vs. RBs
- Week 5, Oct 11,at SEA,ToughSeahawks vs. RBs
- Week 6, Oct 19,vs WAS,ToughCommanders vs. RBs
- Week 7, Oct 25,at ATL,ToughFalcons vs. RBs
Matchup rank is PPR points allowed to RBs through Week 4. 1st allows the most, 32nd the fewest.
Should You Start or Roster Isaac Guerendo?
Guerendo's 2024 tape is the reason to care: on just 84 carries he ripped off 420 yards at 5.0 per tote with four scores, and the explosiveness was real -- a 76-yard burst, two runs of 30-plus, a 10.7% explosive-run rate, and a healthy 0.114 EPA per play across 16 games. He chipped in 15 grabs for 152 yards on limited routes, so the receiving floor exists. The catch is opportunity: a 22.9% snap share and 3.1% target share confirm he was strictly a complementary piece.
He's again penciled in to back up Christian McCaffrey, but a torn pectoral suffered in May threatens most of camp and clouds his early availability, while Jordan James and Kaelon Black push for the No. 2 job. With McCaffrey turning 30 off a 450-touch season, the handcuff appeal is genuine, yet a sub-100 RB ADP and uncertain timeline make him a late-round lottery ticket, not a target.
Career Fantasy Stats by Season
| Season | Team | GP | Rush yds | Rush TD | Rec | Rec yds | Rec TD | FPTS | PPG | Finish |
|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | — | 14 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0.1 | RB120 |
| 2024 | SF | 16 | 420 | 4 | 15 | 152 | 0 | 94.2 | 5.9 | RB48 |
| Career | 30 | 420 | 4 | 15 | 152 | 0 | 95.2 | 3.2 |
Rest-of-Season Outlook and Availability
Guerendo is listed pup.
Injury status
PUP
He has missed 3 games this season. Career games missed to injury: 1. Injury history
- 2025unknownPlayed through
- 2025shoulderPlayed through
- 2024kneePlayed through
- 2024hamstring1 game
Outlook
He's again penciled in to back up Christian McCaffrey, but a torn pectoral suffered in May threatens most of camp and clouds his early availability, while Jordan James and Kaelon Black push for the No. 2 job. With McCaffrey turning 30 off a 450-touch season, the handcuff appeal is genuine, yet a sub-100 RB ADP and uncertain timeline make him a late-round lottery ticket, not a target. Full outlook
RBs like Isaac Guerendo
Isaac Guerendo Fantasy Football FAQ
Should I start Isaac Guerendo in Week 4?
No: Isaac Guerendo is listed as pup for Week 4 against the Broncos, so he should sit. Get the start/sit call for Guerendo.
What are Isaac Guerendo's upcoming fantasy football matchups?
Isaac Guerendo's next three games are Week 4 vs. the Broncos (6th in PPR points allowed to RBs, favorable), Week 5 at the Seahawks (28th in PPR points allowed to RBs, tough) and Week 6 vs. the Commanders (29th in PPR points allowed to RBs, tough). One of them is favorable by points allowed to the position.
Isaac Guerendo 2024 Stats
2024 final · San Francisco 49ersTouchdowns accounted for 25% of his fantasy production, so his weekly output leaned on volume more than scoring.
Rushing
- Yards
- 420
- TD
- 4
- Carries
- 84
5.0 Y/C
Receiving
- Rec
- 15
- Yards
- 152
- TD
- 0
16 Targets
Fantasy (PPR)
- Points
- 94.2
- Pos rank
- RB48
26.8 Best Week 14 CHI−2.0 Worst Week 4 NE
Fantasy Points per Game, Every Season
5.9
Fantasy PPG
RB50
Fantasy finish
26
Rush yds/g
0.9
Rec/g
Isaac Guerendo career stats by season
| Season | GP | Car | Rush yds | Rush TD | Rec | Rec yds | Rec TD | FPTS | PPG | Finish |
|---|---|---|---|---|---|---|---|---|---|---|
| 2025 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1.0 | 0.1 | RB120 |
| 2024 | 16 | 84 | 420 | 4 | 15 | 152 | 0 | 94.2 | 5.9 | RB48 |
| Career | 30 | 84 | 420 | 4 | 15 | 152 | 0 | 95.2 | 3.2 | — |
What His Career Numbers Say
6.3
Career PPG
15 games over 1 season
41%
Availability
Share of team games he played
27%
Top-24 weeks
Share of his games as a top-24 RB
Guerendo has averaged 6.3 fantasy points per game over 15 games and 1 season, without a top-12 finish.
Career numbers describe the past; for what he is worth from here, see Guerendo's rest-of-season rank and trade value in Redraft Command.
Career highs
- 420Rush yards2024
- 4Total TD2024
- 94.2Fantasy pts2024 · RB48
- 572Career scrimmage yds2024–2024
RBs like Isaac Guerendo
Isaac Guerendo Stats FAQ
What were Isaac Guerendo's stats last season?
In 2025, Isaac Guerendo ran for 0 yards and no touchdowns and caught 0 passes for 0 yards in 14 games. That was 1.0 PPR points (0.1 per game), an RB120 finish.
What are Isaac Guerendo's career NFL stats?
Across 2 seasons and 30 games, Isaac Guerendo has 420 rushing yards and 4 rushing touchdowns, plus 15 catches for 152 yards, for 95.2 PPR fantasy points (3.2 per game).
How many touchdowns does Isaac Guerendo have in his career?
Isaac Guerendo has 4 touchdowns in his NFL career: 4 rushing and 0 receiving, over 30 games.
Isaac Guerendo Game Log 2024
Games played
15
FPTS/G (PPR)
6.3
Carries/g
5.6
Rush yds/g
28.0
Rec/g
1.0
Rec yds/g
10.1
Across 15 games in 2024, Isaac Guerendo has averaged 5.6 carries, 28.0 rushing yards and 6.3 PPR fantasy points per game. Isaac Guerendo has finished as a top-12 RB in 3 of those weeks, and inside the top 24 in 4. The best week was Week 14 against CHI (26.8 points); the lowest was Week 4 against NE (-2.0).
| Wk | Opp | Result | FPTS | CAR | RUSH YDS | RUSH TD | TGT | REC | REC YDS | REC TD | Finish |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NYJ27th | W 32-19 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | RB82 |
Week 1 · NYJ · W 32-19 · 0.0 pts
| |||||||||||
| 2 | MIN20th | L 17-23 | 0.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | RB89 |
Week 2 · MIN · L 17-23 · 0.0 pts
| |||||||||||
| 3 | LAR16th | L 24-27 | 1.9 | 5 | 19 | 0 | 0 | 0 | 0 | 0 | RB59 |
Week 3 · LAR · L 24-27 · 1.9 pts
How the 1.9 points scored (PPR)
| |||||||||||
| 4 | NE9th | W 30-13 | -2.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | RB85 |
Week 4 · NE · W 30-13 · -2.0 pts
| |||||||||||
| 5 | ARI13th | L 23-24 | 2.2 | 5 | 22 | 0 | 0 | 0 | 0 | 0 | RB56 |
Week 5 · ARI · L 23-24 · 2.2 pts
How the 2.2 points scored (PPR)
| |||||||||||
| 6 | SEA25th | W 36-24 | 9.9 | 10 | 99 | 0 | 0 | 0 | 0 | 0 | RB28 |
Week 6 · SEA · W 36-24 · 9.9 pts
How the 9.9 points scored (PPR)
| |||||||||||
| 7 | KC32nd | L 18-28 | 1.7 | 1 | 2 | 0 | 1 | 1 | 5 | 0 | RB63 |
Week 7 · KC · L 18-28 · 1.7 pts
How the 1.7 points scored (PPR)
| |||||||||||
| 8 | DAL14th | W 30-24 | 19.2 | 14 | 85 | 1 | 4 | 3 | 17 | 0 | RB10 |
Week 8 · DAL · W 30-24 · 19.2 pts
How the 19.2 points scored (PPR)
| |||||||||||
| 9 | Did not play | ||||||||||
| 10 | TB24th | W 23-20 | 0.0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | RB78 |
Week 10 · TB · W 23-20 · 0.0 pts
| |||||||||||
| 11 | SEA25th | L 17-20 | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | RB78 |
Week 11 · SEA · L 17-20 · 0.0 pts
| |||||||||||
| 12 | Did not play | ||||||||||
| 13 | BUF2nd | L 10-35 | 8.6 | 4 | 19 | 1 | 1 | 1 | -3 | 0 | RB35 |
Week 13 · BUF · L 10-35 · 8.6 pts
How the 8.6 points scored (PPR)
| |||||||||||
| 14 | CHI6th | W 38-13 | 26.8 | 15 | 78 | 2 | 2 | 2 | 50 | 0 | RB2 |
Week 14 · CHI · W 38-13 · 26.8 pts
How the 26.8 points scored (PPR)
| |||||||||||
| 15 | LAR16th | L 6-12 | 11.5 | 16 | 57 | 0 | 4 | 4 | 18 | 0 | RB24 |
Week 15 · LAR · L 6-12 · 11.5 pts
How the 11.5 points scored (PPR)
| |||||||||||
| 16 | Did not play | ||||||||||
| 17 | DET23rd | L 34-40 | 13.9 | 9 | 34 | 0 | 4 | 4 | 65 | 0 | RB11 |
Week 17 · DET · L 34-40 · 13.9 pts
How the 13.9 points scored (PPR)
| |||||||||||
| 18 | ARI13th | L 24-47 | 0.5 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | RB75 |
Week 18 · ARI · L 24-47 · 0.5 pts
How the 0.5 points scored (PPR)
| |||||||||||
Opponent rank is fantasy points allowed to RBs across 2024: 1st allows the most, 32nd the fewest.
Where His Weeks Finished
Four RB1 weeks, two RB2 weeks and nine busts. For a running back ranked RB52 overall, the spread matters more than the average: you get a top-5 ceiling and a waiver-wire floor.
Wk 1 RB82 · Wk 2 RB89 · Wk 3 RB59 · Wk 4 RB85 · Wk 5 RB56 · Wk 6 RB28 · Wk 7 RB63 · Wk 8 RB10 · Wk 10 RB78 · Wk 11 RB78 · Wk 13 RB35 · Wk 14 RB2 · Wk 15 RB24 · Wk 17 RB11 · Wk 18 RB75
Game-by-Game Breakdown
Shut down by Arizona
2 carries, 5 yds. 0/0 receiving, 0 yds.
He played 5% of the snaps and handled 2 carries. Just 2.5 yards per carry. A clean, mistake-free game that landed well below his season average.
RB1 week vs. Detroit
9 carries, 34 yds. 4/4 receiving, 65 yds.
He played 61% of the snaps and handled 9 carries. A clean, mistake-free game that landed well above his season average.
RB1 week vs. the Rams
16 carries, 57 yds. 4/4 receiving, 18 yds.
He played 76% of the snaps and handled 16 carries. A clean, mistake-free game that landed well above his season average.
Season high in a win
15 carries, 78 yds, 2 TD. 2/2 receiving, 50 yds.
He played 56% of the snaps and handled 15 carries. A clean, mistake-free game that landed well above his season average.
Steady in a loss at Buffalo
4 carries, 19 yds, 1 TD. 1/1 receiving, -3 yds.
He played 23% of the snaps and handled 4 carries. A clean, mistake-free game that landed well above his season average.
Shut down by Seattle
0 carries, 0 yds. 0/0 receiving, 0 yds.
He played 3% of the snaps and handled 0 carries. A clean, mistake-free game that landed well below his season average.
Held in check by Tampa Bay
1 carries, 0 yds. 0/0 receiving, 0 yds.
He played 5% of the snaps and handled 1 carries. Just 0.0 yards per carry. A clean, mistake-free game that landed well below his season average.
RB1 week vs. Dallas
14 carries, 85 yds, 1 TD. 3/4 receiving, 17 yds.
He played 63% of the snaps and handled 14 carries. A clean, mistake-free game that landed well above his season average.
Shut down by Kansas City
1 carries, 2 yds. 1/1 receiving, 5 yds.
He played 8% of the snaps and handled 1 carries. Just 2.0 yards per carry. A clean, mistake-free game that landed well below his season average.
Efficient in a road win
10 carries, 99 yds. 0/0 receiving, 0 yds.
He played 26% of the snaps and handled 10 carries. A clean, mistake-free game that landed well above his season average.
Shut down by Arizona
5 carries, 22 yds. 0/0 receiving, 0 yds.
He played 14% of the snaps and handled 5 carries. A clean, mistake-free game that landed well below his season average.
Held in check by New England
1 carries, 0 yds. 0/0 receiving, 0 yds. 1 fumble lost.
He played 8% of the snaps and handled 1 carries. Just 0.0 yards per carry. One lost fumble in a game that landed well below his season average.
Shut down by the Rams
5 carries, 19 yds. 0/0 receiving, 0 yds.
He played 14% of the snaps and handled 5 carries. A clean, mistake-free game that landed well below his season average.
Shut down by Minnesota
1 carries, 0 yds. 0/0 receiving, 0 yds.
He played 1% of the snaps and handled 1 carries. Just 0.0 yards per carry. A clean, mistake-free game that landed well below his season average.
Held in check by the Jets
0 carries, 0 yds. 0/0 receiving, 0 yds.
He played 4% of the snaps and handled 0 carries. A clean, mistake-free game that landed well below his season average.
Fantasy Points By Week
- Weekly points
- Season average (6.3)
Last Five Games
FPTS/G (PPR)
12.3
Weeks 13–18
High
26.8
Low
0.5
Carries/g
9.2
Rush yds/g
38.6
Upcoming Matchups
View matchup — San Francisco 49ers vs Denver Broncos
View matchup — San Francisco 49ers vs Seattle Seahawks
View matchup — San Francisco 49ers vs Washington Commanders
View matchup — San Francisco 49ers vs Atlanta Falcons
RBs like Isaac Guerendo
Preseason Projection vs. Reality
Our 2026 Preseason Outlook
Guerendo's 2024 tape is the reason to care: on just 84 carries he ripped off 420 yards at 5.0 per tote with four scores, and the explosiveness was real -- a 76-yard burst, two runs of 30-plus, a 10.7% explosive-run rate, and a healthy 0.114 EPA per play across 16 games. He chipped in 15 grabs for 152 yards on limited routes, so the receiving floor exists. The catch is opportunity: a 22.9% snap share and 3.1% target share confirm he was strictly a complementary piece.
He's again penciled in to back up Christian McCaffrey, but a torn pectoral suffered in May threatens most of camp and clouds his early availability, while Jordan James and Kaelon Black push for the No. 2 job. With McCaffrey turning 30 off a 450-touch season, the handcuff appeal is genuine, yet a sub-100 RB ADP and uncertain timeline make him a late-round lottery ticket, not a target.
What Drives His Outlook
His 2024 rank among the 95 running backs who played at least six games. Each bar is one running back, best on the left; his is highlighted.
Rushing volume
Receiving role
Efficiency
- Yards after contact per carry
- 2.86
- Broken tackles
- 3
- Explosive-run rate
- 10.7%
- Red-zone opportunities
- 14
- Snap share
- 22.9%
- Targets
- 16
What Could Change His Value
Upside
- A soft spotThe Broncos in Week 4 is a top-10 matchup for RBs.Wk 4 DEN, 6thWk 5 SEA, 28thWk 6 WAS, 29thWk 7 ATL, 30th
- Strong efficiency2.86 yards after contact per carry, 7th of 95 RBs in 2024.
Risk
- InjuryHe's pup, pectoral.
- Tough matchupsThe Seahawks in Week 5 (28th) and the Commanders in Week 6 (29th) are among the stingiest defenses against RBs.
RBs like Isaac Guerendo
Isaac Guerendo Fantasy Outlook FAQ
What is Isaac Guerendo's fantasy football upside?
Isaac Guerendo's upside: his efficiency (2.86 yards after contact per carry, 7th of 95 RBs in 2024) gives him a weekly floor to build on and the Broncos in Week 4 is a top-10 matchup for RBs.
What could hurt Isaac Guerendo's fantasy value?
Isaac Guerendo's risks: he is pup, pectoral, his rushing volume (5.3 carries per game, 57th of 95 RBs in 2024) limits his scoring and the Seahawks in Week 5 and the Commanders in Week 6 are tough matchups. See his injury status and history.
How difficult is Isaac Guerendo's remaining fantasy schedule?
Difficult: of his next seven games, 2 come against a top-10 matchup for RBs and 5 against one of the stingiest defenses, by PPR points allowed to the position.
Isaac Guerendo Injury Update & History
Practice participation
Week 4 reports: Wed, Thu, FriGuerendo hasn't appeared on an injury report this season.
Injury History at a Glance
Five logged injuries in one season. Most of his lost time came from a hamstring injury in 2024; nothing else has cost him a game.
Durability
100/100
Games missed
Injuries
Longest absence
Hamstring injury · 2024
Where He's Been Hurt
Marker size shows games missed. A dashed ring means he played through it.
| Body part | Injuries | Games missed |
|---|---|---|
| Hamstring | 1 | 1 |
| Foot / toe | 1 | 0 |
| Knee | 1 | 0 |
| Other | 1 | 0 |
| Shoulder | 1 | 0 |
| Total | 5 | 1 |
Injury risk profile: Moderate
- No body part injured twice
- Questionable in 2025, played through
- 1 game in 1 season
- 5 injuries spread across 5 body parts
Isaac Guerendo Injury History
Every logged injury, most recent first. Games missed are regular-season games.
- 2025
Questionable Played through
Questionable
- 2025
Shoulder Played through
Dealt with a shoulder injury during the 2025 preseason that he appeared to re-aggravate in a game.
- 2024
Knee Played through
Sustained a knee injury at the end of the 2024 season that he was still dealing with in the subsequent preseason.
- 2024
Hamstring 1 game
Suffered a hamstring injury in the Week 15 game against the Los Angeles Rams and was considered unlikely to play the following week.
- 2024
Foot Sprain Played through
Suffered a foot sprain during his first-career start in Week 14 against the Chicago Bears.
RBs like Isaac Guerendo
Isaac Guerendo Injury FAQ
Is Isaac Guerendo injured?
Yes. As of October 2, 2026, Isaac Guerendo is pup list with a pectoral injury. He has missed 3 games this season. See how the injury changes his rest-of-season value.
Is Isaac Guerendo playing this week?
No. Isaac Guerendo is pup list for Week 4 against the Broncos on Sunday, October 4. Should you start him?
What injury does Isaac Guerendo have?
Isaac Guerendo has a pectoral injury and is pup list for Week 4. He has missed 3 games this season.
Why isn't Isaac Guerendo playing?
Isaac Guerendo is pup list with a pectoral injury, the designation his club filed as of October 2, 2026. That rules him out of Week 4.
Has Isaac Guerendo missed any games this season?
Yes. Isaac Guerendo has missed 3 games in 2026 and played in 0.
What is Isaac Guerendo's injury history?
Isaac Guerendo has 5 logged NFL injuries, which have cost him 1 game in all: 1 for a hamstring injury in 2024. No body part has been injured twice.
What was Isaac Guerendo's most recent injury?
Isaac Guerendo's most recent logged injury was a questionable injury in Week 18 of 2025. He played through it and missed no regular-season games.
Does Isaac Guerendo have any recurring injuries?
No. Isaac Guerendo's five logged injuries were to five different body parts, so the record shows no recurring pattern.
What was Isaac Guerendo's worst injury?
Isaac Guerendo's longest absence came from a hamstring injury in 2024, which cost him 1 game, all of the games he has missed to injury.
Latest Isaac Guerendo News & Updates
Season Timeline
Every update this season, grouped by week, newest first.
Week 3Sep 27W 36–30 vs ARI
Game recap coming soon
Week 2Sep 20W 35–13 vs MIA
Game recap coming soon
Week 1Sep 10W 27–7 @ LAR
Game recap coming soon
No updates of this type yet this season.
Around the 49ers
RBs like Isaac Guerendo
Isaac Guerendo Bio
Isaac Guerendo is a running back for the San Francisco 49ers, where he wears No. 31. Born June 28, 2000, he attended Avon and played college football at Wisconsin and then Louisville.
The San Francisco 49ers selected Guerendo in round 4, pick 129, of the 2024 NFL Draft. He was traded to the San Francisco 49ers on April 27, 2024.
In 15 regular-season games since 2024, he has run for 420 yards and 4 touchdowns and caught 15 passes.
Career Timeline
1 stop with 1 team in 3 seasons. Each block's width is the time he spent there.
What happened at each stop
San Francisco 49ers Current team2024–present
Selected in round 4, pick 129, of the 2024 NFL Draft. He was a reserve, playing less than a quarter of the offensive snaps in 25 of 30 games.
College: Wisconsin, Louisville
Transactions
- SignedSigned with the San Francisco 49ers.
- TradedTraded by the New York Jets to the San Francisco 49ers for RB Isaiah Davis and DB Qwan'tez Stiggers.
- DraftedSelected by the San Francisco 49ers in round 4, pick 129.
RBs like Isaac Guerendo
About Isaac Guerendo: Bio FAQ
How old is Isaac Guerendo?
Isaac Guerendo is 26 years old. He was born on June 28, 2000. 2026 is his 3rd NFL season.
How tall is Isaac Guerendo?
Isaac Guerendo is 6 feet tall (6'0"), listed at 221 pounds, and plays running back for the San Francisco 49ers.
How much does Isaac Guerendo weigh?
Isaac Guerendo weighs 221 pounds, his listed weight on the San Francisco 49ers roster. He is listed at 6'0".
What number does Isaac Guerendo wear?
Isaac Guerendo wears number 31 for the San Francisco 49ers. He plays running back.
What position does Isaac Guerendo play?
Isaac Guerendo plays running back for the San Francisco 49ers, wearing number 31. 2026 is his 3rd season in the NFL.
What team does Isaac Guerendo play for?
Isaac Guerendo plays for the San Francisco 49ers as a running back. He has been with the 49ers since 2024.
Where did Isaac Guerendo go to college?
Isaac Guerendo played college football at Louisville, after attending Avon (IN). The San Francisco 49ers drafted him out of Louisville in 2024.
When was Isaac Guerendo drafted?
The San Francisco 49ers selected Isaac Guerendo in the fourth round of the 2024 NFL Draft with the 129th overall pick, out of Louisville.
What round was Isaac Guerendo drafted in?
Isaac Guerendo was a fourth-round pick in the 2024 NFL Draft, taken 129th overall by the San Francisco 49ers.
What pick was Isaac Guerendo in the NFL Draft?
Isaac Guerendo was the 129th overall pick of the 2024 NFL Draft, selected by the San Francisco 49ers in the fourth round.
Where is Isaac Guerendo from?
Isaac Guerendo went to high school in Indiana, at Avon, before playing college football at Louisville.
When is Isaac Guerendo's birthday?
Isaac Guerendo's birthday is June 28. He was born on June 28, 2000 and is 26 years old.
How long has Isaac Guerendo been in the NFL?
2026 is Isaac Guerendo's 3rd NFL season; he entered the league in 2024 as a fourth-round pick of the San Francisco 49ers. View his career statistics.
What teams has Isaac Guerendo played for?
Isaac Guerendo has played for the San Francisco 49ers. View his career statistics.
What year did Isaac Guerendo enter the NFL?
Isaac Guerendo entered the NFL in 2024, when the San Francisco 49ers drafted him in the fourth round. 2026 is his 3rd season.